This invention relates to biomimetic implants containing mammalian cells which are induced by their environment to produce gradients of diffusible factors. This may be useful in eliciting a physiological pro-angiogenic response which stimulates angiogenesis and revascularisation in tissue adjacent the implant, for example in therapeutic applications in which increased angiogenesis and/or vasculogenesis is required. This may also be useful in providing biomimetic mammalian cell niches for cell culture and differentiation.
 

Inventors:   Brown, Robert (Middlesex, GB) 
                     Cheema, Umber (Middlesex, GB) 
                     Macrobert, Sandy (London, GB) 
                     Hadjipanayi, Ektoras (Middlesex, GB) 

Application Number: 12/991396

Publication Date: 11/12/2013