Journal of Bionic Engineering (2021) 18:1378–1390 https://doi.org/10.1007/s42235-021-00115-7

Electrospun Scafold of Collagen and Polycaprolactone Containing ZnO Quantum Dots for Skin Wound Regeneration 

Pengfei Li1  · Liming Ruan2  · Ruofan Wang1,2 · Tianqi Liu1  · Gao Song1  · Xiaofei Gao1  · Guohua Jiang1,3,4  · Xiaoyan Liu5

1 School of Materials Science and Engineering, Zhejiang SciTech University, Hangzhou 310018, China 2 Department of Dermatology, Beilun People’s Hospital of Ningbo City, Ningbo 315800, China
3 Zhejiang-Mauritius Joint Research Center for Biomaterials and Tissue Engineering, Zhejiang Sci-Tech University, Hangzhou 310018, China
4 Institute of Smart Biomedical Materials, Zhejiang Sci-Tech University, Hangzhou 310018, China
5 Department of Dermatology, The 1st Afliated Hospital of Zhejiang University, Hangzhou 310003, China

Abstract Nanofbers (NFs) have been widely used in tissue engineering such as wound healing. In this work, the antibacterial ZnO quantum dots (ZnO QDs) have been incorporated into the biocompatible poly (ε-caprolactone)/collagen (PCL/Col) fbrous scafolds for wound healing. The as-fabricated PCL-Col/ZnO fbrous scafolds exhibited good swelling, antibacterial activity, and biodegradation behaviors, which were benefcial for the applications as a wound dressing. Moreover, the PCL-Col/ZnO fbrous scafolds showed excellent cytocompatibility for promoting cell proliferation. The resultant PCL-Col/ZnO fbrous scafolds containing vascular endothelial growth factor (VEGF) also exhibited promoted wound-healing efect through promoting expression of transforming growth factor-β (TGF-β) and the vascular factor (CD31) in tissues in the early stages of wound healing. This new electrospun fbrous scafolds with wound-healing promotion and antibacterial property should be convenient for treating wound healing. 

Keywords Wound dressing · Issue engineering scafold · Wound healing · Electrospun nanofbers

Schematic illustration of electrospun PCL/Col scaffolds containing of ZnO QDs and VEGF for skin wound healing