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[2021-Vol.18-Issue 6]Silk Fibroin and κ-Carrageenan Composite Films Containing Zinc-doped Bioactive Glass for Wound Closure
Post: 2021-12-23 13:47  View:403

Journal of Bionic Engineering (2021) 18:1400–1412  https://doi.org/10.1007/s42235-021-00105-9

Silk Fibroin and κ-Carrageenan Composite Films Containing Zinc?doped Bioactive Glass for Wound Closure

Ruofan Wang1  · Liming Ruan2  · Pengfei Li1  · Tianqi Liu1  · Guohua Jiang1,3,4

1 School of Materials Science and Engineering, Zhejiang SciTech University, Hangzhou 310018, China
2 Department of Dermatology, Beilun District People’s Hospital of Ningbo City, Ningbo 315800, China
3 Zhejiang-Mauritius Joint Research Center for Biomaterials and Tissue Engineering, Zhejiang Sci-Tech University, Hangzhou 310018, China
4 Institute of Smart Biomedical Materials, Zhejiang Sci-Tech University, Hangzhou 310018, China

Abstract  Natural biopolymers have excellent biocompatibility and biodegradability; they can be used as biomedical materials for wound healing. In this work, the Silk Fibroin (SF) and κ-carrageenan (κ-Car) composite flms containing Zinc-doped Bioactive Glass (ZBG) have been fabricated for wound closure applications. The as-fabricated SF–κ-Car/ZBG composite flms have excellent stretchability and foldability, which facilitates them for application as wound dressing. They also exhibit excellent hydrophilicity and water-absorption capacity, which can efectively absorb wound exudate and keep the wound sites under moist state. In addition, the composite flms have a good antibacterial efect against S. aureus and E. coli in vitro, which can reduce the risk of wound infection. Their excellent cell compatibility is confrmed by the CCK-8 assay. The strong vascular proliferation and wound regeneration are found in SF–κ-Car/ZBG composite flms on a mouse skin wound model. The SF–κCar/ZBG composite flms can inhibit the secretion of infammatory factors, and stimulate the production of vascular factors and collagen fbers. The results derived from the performed investigations revealed that the SF–κ-Car/ZBG composite flms are a promising candidate dressing for wound healing applications. 

Keywords Wound dressings · Silk fbroin · κ-Carrageenan · Zinc-doped bioactive glass · Wound healing

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SEM images of the surface and cross-sectional morphologies of SF–κ-Car-1, SF–κ-Car-2, SF–κ-Car-3 composite films before and after swelling

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