[2022-Vol.19-Issue 2]3D Biocompatible Polyester Blend Scaffolds Containing Degradable Calcium Citrate for Bone Tissue Engineering
Post: 2022-04-08 10:38  View:149

Journal of Bionic Engineering (2022) 19:497–506 

3D Biocompatible Polyester Blend Scafolds Containing Degradable Calcium Citrate for Bone Tissue Engineering 

Yifei Xiao1  · Li Wang1  · Kun Luo1  · Yanan Yang1  · Peicong Zhang1  · Junfeng Li1 

1 College of Materials, Chemistry and Chemical Engineering, Chengdu University of Technology, Chengdu 610059, Sichuan, People’s Republic of China

Abstract In this study, a novel porous 3D composite scafold based on the biodegradable Poly(ε-caprolactone) (PCL), Polylactide Acid (PLA) and Calcium Citrate (CC) was developed via polymer blends and thermal-induced phase separation. The chemical structure, crystalline structure and micromorphology as well as mechanical strength of the scafolds were characterized by Fourier Transform Infrared Spectroscopy (FTIR), X-ray Difraction (XRD), Scanning Electron Microscope (SEM) and tensile tests. The results show that the obtained composite scafold present a suitable bone-like porous structure and sufcient mechanical strength. Furthermore, the release of calcium ions in Simulated Body Fluid (SBF) indicates that the composite material can provide a stable calcium-ion environment and maintain a constant pH value during the soaking process. The cell proliferation results from CCK-8 and light microscopy show that MG63 cells exhibit excellent adhesion and proliferation on the stent. At the same time, animal implantation histology confrms that the composite scafolds have good biocompatibility in vivo. The scafold material has greatly potential application value in the feld of bone tissue engineering. 

Keywords  3D scafolds · Calcium citrate · Degradable polyester · High mineralization · pH stabilization · Biocompatibility


a Chemical structure of PCL, PLA and CC. b Preparation of composite scaffolds by thermal-induced phase separation

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